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COMPLEMENT C1
Descriptors Found:
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DeCS
Descriptor
English
:
Complement C1
Descriptor
Spanish
:
Complemento C1
Descriptor
Portuguese
:
Complemento C1
Tree Number:
D12.776.124.486.274.050
Definition
English
:
The first complement component to act in the activation of
CLASSICAL COMPLEMENT PATHWAY
. It is a calcium-dependent trimolecular complex made up of three subcomponents:
COMPLEMENT C1Q
;
COMPLEMENT C1R
; and
COMPLEMENT C1S
at 1:2:2 ratios. When the intact C1 binds to at least two
antibodies
(involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of
COMPLEMENT ACTIVATION.
Indexing Annotation
English
:
/antag permitted but consider also
COMPLEMENT C1 INACTIVATOR PROTEINS
Pharmacological Action:
Immunologic Factors
History Note
English
:
2006 (1975)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22133
Unique Identifier:
D003172
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS